Glucagon-Like Peptide-1 (GLP-1) is a potent incretin hormone produced in the L-cells of the intestines. It is released into the bloodstream after eating and performs several essential functions to maintain glucose homeostasis, including stimulating insulin secretion, inhibiting glucagon release, and slowing gastric emptying. These actions ensure that nutrients are absorbed gradually and that blood sugar levels remain within a healthy range.
GLP-1 also acts directly on the satiety centers of the brain to reduce hunger and increase the feeling of fullness. Because of these powerful effects on both metabolism and appetite, GLP-1 receptor agonists have become a cornerstone in the treatment of type 2 diabetes and obesity. By mimicking the action of the natural hormone, these medications help individuals achieve significant weight loss and improve their overall metabolic profile.
The definitive guide by Russell Clark, FNP-C, APRN