The biochemical process of fatty acid and triglyceride synthesis from glucose or other substrates. This process occurs predominantly in the liver and adipose tissue. It is highly active during the 'fed state' when blood glucose and insulin levels are elevated, ensuring that excess energy is stored for future use.
In the modern dietary context, chronic lipogenesis leads to the expansion of adipose tissue (obesity) and the accumulation of ectopic fat in organs like the liver and heart. By restricting carbohydrate intake, an individual can downregulate lipogenesis and instead promote lipolysis, the process of breaking down stored fat to be used as an energy source.
The definitive guide by Russell Clark, FNP-C, APRN